Omeprazole in infants with cimetidine-resistant peptic esophagitis.
Authors
Alliet P. Raes M. Bruneel E. Gillis P.
Source
Journal of Pediatrics. 132(2):352-4, 1998 Feb.
Abstract
Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks.
The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants.
Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity. |
