Treatment with sodium alginate of gastroesophageal reflux disease in childhood: efficacy and tolerance assessment
[Article in Italian]
Author
Maestri L.
Source
Pediatr Med Chir. 2001 May-Aug;23(3-4):187-9. Italian.
Abstract
Objective: Evaluation of efficacy of sodium alginate (Gaviscon) in the treatment of gastroesophageal reflux disease in children 3-12 months old, assessed by 24 hours esophageal continuous pH monitoring.
Method: 28 children studied by 24 hours pH esophageal continuous monitoring before starting the treatment with Gaviscon 0.5 ml/Kg/dose four times a day, 20 minutes after meal. After 2 months of treatment, a second pH esophageal monitoring was performed, during therapy. Total number of refluxes, number of refluxes longer than 5 minutes and reflux index before and during treatment were evaluated, by multiple regression method.
Results: All pHmetric parameters showed a statistically significative improvement after 60 days of treatment.
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